黄体期对比卵泡期卵巢切除术他莫昔芬用于

　　年4月20日，欧洲癌症研究与治疗组织（EORTC）、欧洲癌症组织（ECCO）、欧洲癌症研究学会（EACR）、欧洲乳腺癌专家学会（EUSOMA）官方期刊《欧洲癌症杂志》（EJC）在线发表了美国（国际乳腺癌研究基金会、俄亥俄州立大学）、中国（医院、医院、医院医院、中国医学科学院北医院、医院、首都医科医院、国立台医院）、孟加拉国（医院、医院、国医院、邦格班杜·谢赫·穆吉医院、阿马德·格兰乳腺癌中心）、菲律宾（医院、维森特·医院、黎刹医学中心、医院）、尼日利亚（医院）、印度尼西亚（医院）、马来西亚（马来亚大学医学中心）的随机对照研究，发现：

卵巢切除术＋他莫昔芬对于条件受限患者是有效的治疗方法

卵泡期长的月经周期史不准确

卵泡期长的患者卵巢切除术生存较差

某些患者存在围手术期不良反应

根据月经周期史决定卵巢切除术时机不影响转移性患者结局

EurJCancer.;60:-.

Lutealversusfollicularphasesurgicaloophorectomyplustamoxifeninpremenopausalwomenwithmetastatichormonereceptor-positivebreastcancer.

LoveRR,HossainSM,HussainMM,MostafaMG,LaudicoAV,SiguanSS,AdebamowoC,SunJZ,FeiF,ShaoZM,LiuY,AkramHussainSM,ZhangB,ChengL,PanigaroS,WaltaF,ChuanJH,Mirasol-LumagueMR,YipCH,NavarroNSJr,HuangCS,LuYS,FerdousyT,SalimR,AkhterC,NaharS,UyG,YoungGS,HadeEM,JarjouraD.

TheInternationalBreastCancerResearchFoundation,USA.

KhulnaMedicalCollegeandHospital,Khulna,Bangladesh.

DhakaMedicalCollegeandHospital,Dhaka,Bangladesh.

NationalCancerResearchInstituteandHospital,Dhaka,Bangladesh.

PhilippinesGeneralHospital,Manila,Philippines.

VicenteSottoMemorialHospital,Cebu,Philippines.

UniversityCollegeHospital,Ibadan,Nigeria.

QiluHospital,Jinan,China.

CancerInstitute,FudanUniversity,Shanghai,China.

4thHospital,Hebei,China.

BSMMUPostgraduateHospital,Dhaka,Bangladesh.

CancerInstituteandHospital,ChineseAcademyofMedicalSciencesandPekingUnionMedicalCollege,Beijing,China.

PeoplesHospital,Beijing,China.

UniversityofIndonesiaGeneralHospital,Jakarta,Indonesia.

ChaoYangHospital,Beijing,China.

RizalMedicalCenter,PasigCity,Philippines.

UniversityofMalayaMedicalCenter,KualaLumpur,Malaysia.

SantoThomasUniversityHospital,Manila,Philippines.

NationalTaiwanUniversityHospital,Taipei,Taiwan.

AmaderGram,Khulna,Bangladesh.

TheOhioStateUniversityCenterforBiostatistics,Columbus,Ohio,USA.

Highlights

Surgicaloophorectomy+tamoxifenisgoodtherapyinpatientswithlimitedresources.

Menstrualcyclehistoriesareinaccuratebecauseoflongfollicularphases.

Patientswithlongfollicularphasestendtohavepoorersurvivalwithoophorectomy.

Withotherdata,thisstudysuggestsperi-operativeadverseeffectsinsomepatients.

PURPOSE:Inpremenopausalwomenwithmetastatichormonereceptor-positivebreastcancer,hormonaltherapyisthefirst-linetherapy.Gonadotropin-releasinghormoneanalogue+tamoxifentherapieshavebeenfoundtobemoreeffective.Thepatternofrecurrenceriskovertimeafterprimarysurgerysuggeststhatperi-operativefactorsimpactrecurrence.Secondaryanalysesofanadjuvanttrialsuggestedthatthelutealphasetimingofsurgicaloophorectomyinthemenstrualcyclesimultaneouswithprimarybreastsurgeryfavourablyinfluencedlong-termout







































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